Aggressive central giant cell granuloma mimicking giant cell tumor

Introduction: Giant cell granulomas (GCGs) of the jaws are lesions that arise either peripherally in periodontal ligament, mucoperiosteum, or centrally in the bone. Histologically, both peripheral and central giant cell granuloma (CGCG) are characterized by the presence of numerous multinucleated giant cells (MGCs) in a prominent fibrous stroma. CGCG are further categorized into aggressive and non aggressive variant. Case Report: The present case highlights the difficulty in diagnosing aggressive CGCGs from Giant cell tumors (GCT), with which they share similar histopathology, behaviour and prognosis. Discussion: The recurrent nature of the present case and the extensive destruction caused in the hard and soft tissues suggests the possibility of true ‘tumors’ (Giant cell tumors) existing in the jaw.